118ͼ¿â

2^nd June

Monday, Day 1

1200

Registration and refreshments

1300

1305

Welcome Address –Adrian Harris (University of Oxford)

PPI Speaker:  Elspeth Banks, (Independent Cancer Patients' Voice)

1315

Opening Keynote:

Steve Jackson (Cancer Research UK Cambridge Institute)

Cellular responses to DNA damage: mechanistic insights and therapeutic implications

Session 1: Genes, Mutation and Repair

1400

Jo Morris (University of Birmingham)

TBC

1430

Helen Bryant (University of Sheffield)

DNA repair inhibitors - beyond PARP and BRCAness

1500

1515

1530

Short talk

Short talk

Coffee/Tea

1600

Kristian Helin, (ICR, London)

New Therapeutic targets for Acute Myeloid Leukaemia

1630

Susan Gasser, (ISREC, Lausanne, Switzerland)

Roles of chromatin and nucleosome remodelers in genome stability

1700

1715

1930

118ͼ¿â AstraZeneca Young Scientist Award 2023

Luca Magnani, (ICR, London)

Sleepwalking through evolution: a tale of dormancy and hormone dependent breast cancer

Welcome drinks and finger buffet

Poster Session 1 (Odd Numbers)

Speakers’ Dinner

3rd June

Tuesday, Day 2

Session 2: The Tumour Ecosystem

0900

Kairbaan Hodivala-Dilke (Barts Cancer Institute, QMUL)

Tumour blood vessels and b3-integrin: Converging stories

0930

Leanne Li  (Francis Crick Institute, London)

Behind the scenes:  Neuronal orchestration of the tumour microenvironment

1000

Short talk

1015

Short Talk

1030

Tea/Coffee

1100

Derek Mann (University of Newcastle)

Manipulating neutrophils to repgroamme the tumour microenvironment of hepatocellular carcinoma

1130

1200

Erik Sahai (Francis Crick Institute, London)

Modelling the tumour - stroma interface

118ͼ¿â Chris Marshall Prize for Cell Signalling TBC

Yaiza Jung Garcia (Lothian University, Edinburgh)

LAP1 supports nuclear adaptability during constrained melanoma cell migration and invasion

1215

Lunch Posters and Exhibition

(12.40 to 13.00  Commercial Workshop)

Session 3: Immune cells and immunotherapy

1400

Mark Cragg (University of Southampton)

Engineering antibodies for immune stimulation

1430

Santiago Zeleny (Cancer Research UK Manchester Institute)

The dual role of inflammation in cancer immunity

1500

Short Talk

1515

Short talk

1530

Coffee/Tea

1600

Eileen Parkes (University of Oxford)

Chromosomal instability shapes the tumour microenvironment

1630

Ed Roberts (Cancer Research UK Scotland Institute, Glasgow)

Failure to recruit lymph node resident cDC1 results in poorly functional anti-tumour CD8 T cell responses

1700

1900

Drinks Reception

Poster Session 2 (Even Numbers)

Conference Dinner (Venue to be confirmed)

4^thJune

Wednesday, Day 3

Session 4: Models, Screening, Profiling and Imaging

0900

Mathew Garnett (Sanger Institute, Cambridge)

Mapping Cncer Dependencies to Guide Precision Cancer Medicine

0930

Philip Dunne (Queens University, Belfast)

The molecular and phenotypic landscapes in colorectal cancer

1000

Short Talk (Cardiff University)

1015

Short Talk

1030

Tea/Coffee

1100

1130

Eugenia Piddini (University of Bristol)

p53-mediated stem cell competition: Insights into mechanisms of clonal dominance

Noor Gammoh (University of Edinburgh)

Modelling the role of autophagy in brain tumour development

1200

1230

118ͼ¿â/AstraZeneca Frank Rose Award (2022) Stephen Sammut (ICR)

Stephen-John Sammut, (ICR, London)

Ending uncertainty: predicting response to breast cancer treatment using tumour profiling and AI.

Lunch

Session 5:  Novel Therapeutic Strategies and Early Detection

1315

1345

Pascal Meier (ICR, London)

The Power of Death:  Harnessing Immunogenic Cell Death in Cancer

Louise Fets (MRC/Imperial College London)

Heterogeneous drug accumulation in cancer - why concentration matters

1415

1430

Short Talk

Short Talk

1445

1515

1545

Tea/Coffee

Alan Parker   (Cardiff University)

Development of precision virotherapies for "in-tumour" expression of theapeutics

Closing Keynote: Rene Bernards (Netherlands Cancer Institute, Amsterdam)

Behave or die, a novel approach to cancer therapy

1630

Awards Ceremony and Closing Remarks